diff --git a/index.d.ts b/index.d.ts
index 8a9926d8d..b04095430 100644
--- a/index.d.ts
+++ b/index.d.ts
@@ -50,6 +50,7 @@ export type {SetReadonly} from './source/set-readonly.d.ts';
 export type {SetRequired} from './source/set-required.d.ts';
 export type {SetRequiredDeep} from './source/set-required-deep.d.ts';
 export type {SetNonNullable} from './source/set-non-nullable.d.ts';
+export type {SetNullable} from './source/set-nullable.d.ts';
 export type {SetNonNullableDeep} from './source/set-non-nullable-deep.d.ts';
 export type {ValueOf} from './source/value-of.d.ts';
 export type {AsyncReturnType} from './source/async-return-type.d.ts';
diff --git a/readme.md b/readme.md
index 47e9fee30..642dd5d00 100644
--- a/readme.md
+++ b/readme.md
@@ -133,6 +133,7 @@ Click the type names for complete docs.
 - [`SetReadonly`](source/set-readonly.d.ts) - Create a type that makes the given keys readonly.
 - [`SetRequired`](source/set-required.d.ts) - Create a type that makes the given keys required.
 - [`SetRequiredDeep`](source/set-required-deep.d.ts) - Like `SetRequired` except it selects the keys deeply.
+- [`SetNullable`](source/set-nullable.d.ts) - Create a type that makes the given keys nullable.
 - [`SetNonNullable`](source/set-non-nullable.d.ts) - Create a type that makes the given keys non-nullable.
 - [`SetNonNullableDeep`](source/set-non-nullable-deep.d.ts) - Create a type that makes the specified keys non-nullable (removes `null` and `undefined`), supports deeply nested key paths, and leaves all other keys unchanged.
 - [`ValueOf`](source/value-of.d.ts) - Create a union of the given object's values, and optionally specify which keys to get the values from.
diff --git a/source/set-nullable.d.ts b/source/set-nullable.d.ts
new file mode 100644
index 000000000..327c21b72
--- /dev/null
+++ b/source/set-nullable.d.ts
@@ -0,0 +1,35 @@
+/**
+Create a type that makes the given keys nullable, where the remaining keys are kept as is.
+
+If no keys are given, all keys will be made nullable.
+
+Use-case: You want to define a single model where the only thing that changes is whether or not some or all of the keys are nullable.
+
+@example
+```
+import type {SetNullable} from 'type-fest';
+
+type Foo = {
+	a: number;
+	b: string;
+	c?: boolean;
+};
+
+type SomeNullable = SetNullable<Foo, 'a' | 'c'>; // Optionality is preserved for `c`
+//=> {a: number | null; b: string; c?: boolean | null}
+
+type AllNullable = SetNullable<Foo>;
+//=> {a: number | null; b: string | null; c?: boolean | null}
+```
+
+@see {@link SetNonNullable}
+
+@category Object
+*/
+export type SetNullable<BaseType, Keys extends keyof BaseType = keyof BaseType> = {
+	[Key in keyof BaseType]: Key extends Keys
+		? BaseType[Key] | null
+		: BaseType[Key];
+};
+
+export {};
diff --git a/test-d/set-nullable.ts b/test-d/set-nullable.ts
new file mode 100644
index 000000000..9202885f8
--- /dev/null
+++ b/test-d/set-nullable.ts
@@ -0,0 +1,57 @@
+import {expectNotAssignable, expectType} from 'tsd';
+import type {SetNullable} from '../index.d.ts';
+
+// Make one key nullable.
+declare const variation1: SetNullable<{a: number; b: string}, 'a'>;
+expectType<{a: number | null; b: string}>(variation1);
+
+// Make multiple keys nullable.
+declare const variation2: SetNullable<{a: number; b: string; c: boolean}, 'a' | 'c'>;
+expectType<{a: number | null; b: string; c: boolean | null}>(variation2);
+
+// Preserve optional modifier.
+declare const variation3: SetNullable<{a: number; b?: string}, 'b'>;
+expectType<{a: number; b?: string | null}>(variation3);
+
+// Key already nullable remains unchanged.
+declare const variation4: SetNullable<{a: number | null; b: string}, 'a'>;
+expectType<{a: number | null; b: string}>(variation4);
+
+// Fail if type changes even if nullable is right.
+declare const variation5: SetNullable<{a: number; b: string}, 'b'>;
+expectNotAssignable<{a: string; b: string | null}>(variation5);
+
+// Make all keys nullable when `Keys` generic is not passed.
+declare const variation6: SetNullable<{a: number; b: string; c: boolean}>;
+expectType<{a: number | null; b: string | null; c: boolean | null}>(variation6);
+
+// Preserve readonly modifier.
+declare const variation7: SetNullable<{readonly a: number; b: string}, 'a'>;
+expectType<{readonly a: number | null; b: string}>(variation7);
+
+// Works with unions.
+declare const variation8: SetNullable<{a: '1'; b: string; c: boolean} | {a: '2'; b: string; c: boolean}, 'a' | 'b'>;
+expectType<{a: '1' | null; b: string | null; c: boolean} | {a: '2' | null; b: string | null; c: boolean}>(variation8);
+
+// Works with index signatures.
+declare const variation9: SetNullable<{[k: string]: unknown; a: number; b: string}, 'a'>;
+expectType<{[k: string]: unknown; a: number | null; b: string}>(variation9);
+
+declare const variation9a: SetNullable<{[k: Uppercase<string>]: number; A: number; b: string}, Uppercase<string>>;
+expectType<{[k: Uppercase<string>]: number | null; A: number | null; b: string}>(variation9a);
+
+// Makes all keys nullable when `Keys` is `any`.
+declare const variation10: SetNullable<{readonly a: number; b?: string; c: boolean}, any>;
+expectType<{readonly a: number | null; b?: string | null; c: boolean | null}>(variation10);
+
+// Does nothing when `Keys` is `never`.
+declare const variation11: SetNullable<{a: number; readonly b?: string; readonly c: boolean}, never>;
+expectType<{a: number; readonly b?: string; readonly c: boolean}>(variation11);
+
+// Preserves existing `undefined` when adding `null`.
+declare const variation12: SetNullable<{a: string | undefined; b: number}, 'a'>;
+expectType<{a: string | undefined | null; b: number}>(variation12);
+
+// Works with unions where only some keys are shared across branches.
+declare const variation13: SetNullable<{a: number; c: boolean} | {a: string; d: boolean}, 'a'>;
+expectType<{a: number | null; c: boolean} | {a: string | null; d: boolean}>(variation13);